| P38和ERK1/2在肝细胞癌中的表达及意义 |
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| 引用本文： | 梁佳,包翠芬,魏嘉,苏荣健. P38和ERK1/2在肝细胞癌中的表达及意义[J]. 中国组织化学与细胞化学杂志, 2009, 18(2): 202-206. DOI: 10.3870/zgzzhx.2009.02.016 |
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| 作者姓名： | 梁佳 包翠芬 魏嘉 苏荣健 |
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| 作者单位： | 辽宁医学院科学实验中心,锦州,121001 |
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| 基金项目： | 辽宁省博士科研启动基金 |
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| 摘 要： | 目的探讨p38（mitogen-activated protein kinase p38,p38）和细胞外信号调节激酶1/2（extracellular reg-ulated kinase 1/2,ERK1/2）在不同分化程度肝细胞癌（human hepatocellular carcinoma,HCC）中的表达情况,以及两者的相关性。方法通过免疫组化（Envision）法,检测52例肝癌组织及l0例癌旁正常肝脏组织中p38和ERK1/2的表达。结果：p38和ERK1/2在肝癌组织中均有表达,与正常组比较差异有显著性,且阳性率的高低与其分化程度有关,p38在肝癌组织中的表达随分化程度的增高阳性率降低（P〈0.05）;ERK1/2在中、低分化的肝癌组织分别与高分化相比差异具有显著性（P〈0.05）。但低分化与中分化的肝癌组织比较虽也有差异但无统计学意义（P〉0.05）。癌组织中p38和ERK1/2的表达呈中度正相关（r=0.703,P〈0.05）。结论HCC中,p38和ERK1/2表达和活性增加,且存在一定的相关性。
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| 关 键 词： | ERK1/2 p38 肝细胞癌 相关性 |
EXPRESSION AND SIGNIFICANCE OF p38 AND ERK1/2 IN HUMAN HEPATOCELLULAR CARCINOMA |
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| Liang Jia,Bao Cuifen,Wei Jia,Su Rongjian. EXPRESSION AND SIGNIFICANCE OF p38 AND ERK1/2 IN HUMAN HEPATOCELLULAR CARCINOMA[J]. Chinese Journal of Histochemistry and Cytochemistry, 2009, 18(2): 202-206. DOI: 10.3870/zgzzhx.2009.02.016 |
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| Authors: | Liang Jia Bao Cuifen Wei Jia Su Rongjian |
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| Affiliation: | Center of Scientific Experiment;Liaoning Medical University;Jinzhou;121001;China |
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| Abstract: | Objective To detect the expression of p38 and ERK1/2 in heaptocellular carcinoma(HCC) and the relationship between the two factors.Methods The expression of ERK1/2 and p38 in HCC was detected by immunohistochemical techniques.There were 10 cases of normal tissue and 50 cases of HCC.Results The expression of ERK1/2 and p38 showed a tendency to increase from low differentiated HCC to high differentiated HCC(P<0.05).The expression of ERK1/2 and p38 in HCC presented a positive correlation(r=0.703,P<0.05).Conclu... |
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| Keywords: | ERK1/2 p38 |
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