Multiple roles of cadmium in cell death and survival |
| |
| Authors: | Douglas M. Templeton Ying Liu |
| |
| Affiliation: | 1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China;2. College of Animal Science and Veterinary Medcine, Henan Agricultural University, Zhengzhou, 450046 Henan, PR China;3. College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, PR China;4. College of Life Science, Foshan University, Foshan, 528231, Guangdong, PR China;5. National Research Institute for Family Planning, Beijing, 100081, PR China;6. Department of Physiology and Pharmacology, Faculty of Animal Science and Veterinary Medicine, Patuakhali Science and Technology University, Barishal, 8210, Bangladesh;7. Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin, 150030, PR China;8. Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin, 150030, PR China;1. Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University (HIU), 5-1-1 Hiro-koshingai, Kure, Hiroshima, 737-0112, Japan;2. Laboratory of Molecular Life Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Sanzou 1, Gakuen-cho, Fukuyama, Hiroshima, 729-0292, Japan;3. Raleigh, NC, 27709, USA;1. Renal Physiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand;2. Cardiac Electrophysiology Research and Training Center, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand;1. National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA;2. Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan;3. Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA |
| |
| Abstract: | Cadmium is a toxic metal with no known biological function. It is increasingly important as an environmental hazard to both humans and wildlife, and it exemplifies the double edged nature of many toxic substances. Thus, on the one hand cadmium can act as a mitogen, stimulate cell proliferation, inhibit apoptosis, inhibit DNA repair, and promote cancer in a number of tissues. On the other hand, it causes tissue damage, notably in the kidney, by inducing cell death. At low and moderate concentrations in cell culture systems (e.g., 0.1–10 μM) cadmium primarily causes apoptosis, and at higher concentrations (>50 μM) necrosis becomes evident. This generalization appears to hold in vivo. There is also evidence of cadmium-induced autophagy, although whether this is a direct cause of cell death remains uncertain. After discussing these generalities, this review considers the details of apoptotic death, and its inhibition, in renal mesangial cells. We also present evidence for the effect of environmental exposure to cadmium in affecting renal function, and in particular review the evidence for the role of the mesangial cell in cadmium nephrotoxicity. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
