Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice |
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| Authors: | Myoung-Nam Woo Seon-Min Jeon Hye-Jin Kim Mi-Kyung Lee Su-Kyung Shin Young Chul Shin Yong-Bok Park Myung-Sook Choi |
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| Institution: | 1. Department of Nutrition and Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan;2. Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan;3. Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 811, Taiwan;4. American Medical Holdings Inc., 1440 Forest Hill Rd., NY, NY 10314;5. Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, USA;6. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan;1. Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, K.S.A;2. Department of Pharmaceutical Biology, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany;3. Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, 71524 Assiut, Egypt;1. Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA;2. Natural Product Research Center, Korea Institute of Science and Technology, 679 Saimdang-ro, Gangneung 210-340, Republic of Korea;3. Department of Biochemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi Arabia;1. School of Food Science and Environmental Health, Dublin Institute of Technology, Cathal Brugha Street, Dublin 1, Ireland;2. School of Chemical and Pharmaceutical Sciences, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland |
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| Abstract: | This study investigated the effects of fucoxanthin isolated from marine plant extracts on lipid metabolism and blood glucose concentration in high-fat diet fed C57BL/6N mice. The mice were divided into high-fat control (HFC; 20% fat, w/w), low-fucoxanthin (low-Fxn; HFC + 0.05% Fxn, w/w) and high-fucoxanthin (high-Fxn; HFC + 0.2% Fxn, w/w) groups. Fxn supplementation significantly lowered the concentration of plasma triglyceride with a concomitant increase of fecal lipids in comparison to the HFC group. Also, the hepatic lipid contents were significantly lowered in the Fxn supplemented groups which seemed to be due to the reduced activity of the hepatic lipogenic enzymes, glucose-6-phosphate dehydrogenase, malic enzyme, fatty acid synthase and phosphatidate phosphohydrolase and the enhanced activity of β-oxidation. Plasma high-density lipoprotein cholesterol concentrations and its percentage were markedly elevated by Fxn supplementation. Activities of two key cholesterol regulating enzymes: 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A: cholesterol acyltransferase, were significantly suppressed by Fxn regardless of the dosage. Relative mRNA expressions of acyl-coA oxidase 1, palmitoyl (ACOX1) and peroxisome proliferators activated receptor α (PPARα) and γ (PPARγ) were significantly altered by Fxn supplementation in the liver. Fxn also lowered blood glucose and HbA1c levels along with plasma resistin and insulin concentrations. These results suggest that Fxn supplementation plays a beneficial role in not only regulating the plasma and hepatic lipids metabolism but also for blood glucose-lowering action in high-fat fed mice. |
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