Migration inhibition of alloimmune mouse macrophages by soluble transplantation antigens |
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| Authors: | K.T. Maehara K.L. McIvor |
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| Affiliation: | Department of Bacteriology and Public Health, Washington State University, Pullman, Washington, 99163 U.S.A. |
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| Abstract: | Specific allogeneic transplantation antigens were solubilized and shown to inhibit the migration of alloimmune macrophages. Alloimmune macrophages treated with trypsin prior to antigen exposure migrated in the presence of the specific soluble antigens. The arming of nonimmune macrophages and the rearming of trypsinized immune macrophages with hyperimmune serum was readily observable using the migration inhibition test, whereas immune serum was ineffective. |
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| Keywords: | Requests for reprints should be addressed to this author at Baltimore Cancer Research Center 3100 Wyman Park Drive Baltimore MD 21211. |
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