The modifying effect of manganese on the enzymic profiles and pathways of carbohydrate metabolism in rat liver and adipose tissue during development |
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Authors: | Najma Zaheer Baquer John S. Hothersall A.L. Greenbaum Patricia McLean |
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Affiliation: | 1. Courtauld Institute of Biochemistry, The Middlesex Hospital Medical Scoool, London, W1P 5PR, UK;2. Department of Biochemistry, University College London, London, WC1E 6BT, Great Britain |
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Abstract: | The effect of Mn2+ on the pattern of emergence of enzymes in rat liver and adipose tissue was studied in weaned rats given a milk diet (high fat) or sucrose-casein diet (high carbohydrate) for three weeks. Addition of Mn2+ to the high fat diet was associated with induction of key glycolytic, lipogenic and pentose pathway enzymes in both liver and adipose tissue; parallel increases were found in the incorporation of [1-14C] glucose into lipid and CO2. Mn2+ induced a change in the profile of enzyme activity similar in pattern to that found in rats given a high sucrose diet or that produced by insulin treatment. Mn2+ appears partially to overcome the regulatory feed-back mechanisms of the high fat diet and to provide a signal for the coordinated increase of glucose catabolic and lipogenic processes. |
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