Step conductance increases in bilayer membranes induced by antibody-antigen-complement action |
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| Authors: | Darold Wobschall Catherine McKeon |
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| Institution: | Department of Biophysical Sciences and Electrical Engineering, State University of New York, Buffalo, N.Y. 14214 USA |
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| Abstract: | A sharp rise in the electrical conductance of lipid bilayer membranes was observed following the addition of antigen (bovine serum), antibody (rabbit anti-bovine serum), and complement to the neighboring aqueous phases. At low concentrations, step increases in the conductivity occurred which are consistent with the appearance of about 2.2 nm holes in the membrane. Probably attack or lysis of the lipid bilayer by complement is responsible. |
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