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Effect of procaine hydrochloride on DNA repair in Escherichia coli |
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| Authors: | C.K.K. Nair D.S. Pradhan |
| Affiliation: | Biochemistry and Food Technology Division, Bhabha Atomic Research Centre, Trombay, Bombay -85 India |
| Abstract: | Liquid-holding recovery and rejoining of γ-radiation-induced DNA singlestrand scissions in Escherichia coli could be effectively inhibited by procaine hydrochloride at the concentration of 20 m M. At this concentration, the drug also reversibly altered cellular permeability barrier as evidenced from the uptake of acriflavin by bacterial cells. |
| Keywords: | BP benzo(a)pyrene DMBA 7,12-dimethylbenzanthracene GDPH glyceraldehyde-3-phosphate dehydrogenase LDH lactic acid dehydrogenase MeO-DMBA 7-methoxyinethyl-12-methylbenz(a)anthracene TCA trichloroaoetic acid |
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