The Cytochrome P4501A1 gene polymorphisms and idiopathic male infertility risk: A meta-analysis |
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Authors: | Jianzheng Fang Shangqian Wang Hainan Wang Shengli Zhang Shifeng Su Zhen Song Yunfei Deng Jian Qian Jinbao Gu Bianjiang Liu Jingyi Cao Zengjun Wang |
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Affiliation: | 1. State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China;2. Department of Urology, Xuzhou Third People''s Hospital, Xuzhou 221000, China |
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Abstract: | Studies of the relationship between male infertility and CYP1A1 polymorphisms are inconclusive. To drive a more precise estimation, we performed a meta-analysis based on 1060cases and 1225 controls from 7 published case–control studies. PubMed and CNKI literature search were conducted to identify all eligible studies investigating such a relationship. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the additive model, dominant model, recessive model, and allele-frequency genetic model. In the overall analysis, the frequency of CYP1A1*2A genotype was significantly associated with susceptibility to idiopathic male infertility. Further stratified analysis by ethnicity showed notable association between the polymorphism and the risk of idiopathic male infertility in Asians. In conclusion, these results support that the CYP1A1*2A genotype polymorphism mainly contributes to idiopathic male infertility susceptibility in Asians but not in Caucasians. |
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Keywords: | CYP1A1, Cytochrome P4501A1 SNPs, single-nucleotide polymorphisms CI, confidence interval OR, odds ratio |
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