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Chitin induces type IV collagen and elastic fiber in implanted non-woven fabric of polyester |
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| Authors: | S Minami Y Okamoto K Miyatake A Matsuhashi Y Kitamura T Tanigawa Y Tanaka Y Shigemasa |
| Institution: | a Department of Veterinary Surgery, Faculty of Agriculture, Tottori University, Tottori 680, Japan b Department of Bacteriology, Faculty of Medicine, Tottori University, Tottori 680, Japan c Department of Pathology, Faculty of Medicine, Tottori University, Tottori 680, Japan d Department of Materials Sciences, Faculty of Engineering, Tottori University, Tottori 680, Japan |
| Abstract: | The non-woven fabric of polyester (control) and the composite material of the non-woven fabric of polyester and chitin (Chitipack P) were implanted to bovine flexor tendon. After 3 weeks implantation, type IV collagen and elastic fibers were significantly increased and type I collagen was decreased in Chitipack P in comparison with control. The breaking strength was about twice as high in Chitipack P than in control. The polykaryocytes in the control were more difficult to digest for the collagens. Angiogenesis in the implanted non-woven fabric and in the neighboring resected tendons was much stronger in Chitipack P. Chitin induced type IV collagen and elastic fibers in the prostheses. |
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