Regulatory T cell responses: potential role in the control of atherosclerosis |
| |
Authors: | Mallat Ziad Ait-Oufella Hafid Tedgui Alain |
| |
Affiliation: | Institut National de la Santé et de la Recherche Médicale, Inserm U689, Cardiovascular Research Center Lariboisière, and University Paris 7, Paris, France. mallat@larib.inserm.fr |
| |
Abstract: | PURPOSE OF REVIEW: Atherosclerosis is an inflammatory disease of the arterial wall where both innate and adaptive Th1-driven immunoinflammatory responses contribute to disease development. Th2-related responses have been shown to be either protective or pathogenic. Thus, it is unclear whether immunoregulatory activity can modulate disease development. RECENT FINDINGS: Novel subtypes of T cells, called the regulatory T cells, have been shown recently to play a critical role in the maintenance of immunological tolerance against self and non-self antigens and prevent the development of various immunoinflammatory diseases. Preliminary studies suggest a potential role for this type of regulatory T cell response in atherosclerosis. SUMMARY: Here we present a novel view of the immunoinflammatory response in atherosclerosis where natural and/or adaptive regulatory T cell responses modulate both Th1 and Th2 pathogenic responses and play a central role in counteracting disease initiation and progression. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|