Identification of the benzodiazepines as a new class of antileishmanial agent |
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| Authors: | Clark Rachel L Carter Katharine C Mullen Alexander B Coxon Geoffrey D Owusu-Dapaah George McFarlane Emma Duong Thi M Dao Grant M Helen Tettey Justice N A Mackay Simon P |
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| Affiliation: | Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK. |
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| Abstract: | The continual increase in drug resistance; the lack of new chemotherapeutic agents; the toxicity of existing agents and the increasing morbidity with HIV co-infection mean the search for new antileishmanial agents has never been more urgent. We have identified the benzodiazepines as a structural class for antileishmanial hit optimisation, and demonstrated that their in vitro activity is comparable with the clinically used drug, sodium stibogluconate, and that the compounds are not toxic to macrophages. |
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