Cell filamentation in an Escherichia coli K-12 fic mutant caused by theophylline or an adenylate cyclase gene (cya)-containing plasmid |
| |
| Authors: | Makoto Kawamukai Kanehisa Murao Ryutaro Utsumi Michio Himeno Tohru Komano |
| |
| Affiliation: | Institute of Biochemistry of the Medical Faculty, E. Kardelj University of Ljubljana, Ljubljana, Yugoslavia;Department of Chemistry, Bar-Ilan University, Ramat-Gan, Israel |
| |
| Abstract: | Abstract The bioconversion of 17α-ethynyl steroids was effected with 11α-hydroxylase of Rhizopus nigricans . 7β-Hydroxyethisterone was found after the bioconversion of ethisterone, and 10β- and 6β-hydroxy derivatives after the bioconversion of norethisterone. It seems that the ethynyl group prevents steroid-enzyme binding in the normal mode and thus inhibits the formation of an 11α-hydroxylated product. |
| |
| Keywords: | Induced 11α-hydroxylase ethisterone norethisterone |
| 本文献已被 ScienceDirect 等数据库收录！ |
