Inferring and quantifying the role of an intrinsic current in a mechanism for a half-center bursting oscillation |
| |
Authors: | Robert Clewley |
| |
Affiliation: | (1) Neuroscience Institute and Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA |
| |
Abstract: | This paper illustrates an informatic technique for inferring and quantifying the dynamic role of a single intrinsic current in a mechanism of neural bursting activity. We analyze the patterns of the most dominant currents in a model of half-center oscillation in the leech heartbeat central pattern generator. We find that the patterns of dominance change substantially over a cycle, allowing different local reductions to be applied to the model. The result is a hybrid dynamical systems model, which is a piecewise representation of the mechanism combining multiple vector fields and discrete state changes. The simulation of such a model tests explicit hypotheses about the mechanism and is a novel way to retain both mathematical clarity and scientific detail in answering mechanistic questions about a complex model. Several insights into the central mechanism of “escape-release” in the model are elucidated by this analysis and compared with previous studies. The broader application and extension of this technique is also discussed. |
| |
Keywords: | Dominant scale analysis Hybrid dynamical systems reduction Bursting dynamics Model inference Neuroinformatics Central pattern generation |
本文献已被 PubMed SpringerLink 等数据库收录! |