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Central nervous system antiretroviral efficacy in HIV infection: a qualitative and quantitative review and implications for future research |
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| Authors: | Lucette A Cysique Edward K Waters Bruce J Brew |
| Institution: | (1) Departments of Neurology and HIV Medicine, St. Vincent’s Hospital, Sydney, Australia;(2) Brain Sciences, St. Vincent’s Hospital Clinical School, faculty of Medicine, University of New South Wales, Sydney, Australia;(3) St Vincent’s Centre for Applied Medical Research, Sydney, Australia;(4) Biostatistics & Databases Program, Kirby Institute (formerly National Centre in HIV Epidemiology and Clinical Research), University of New South Wales, Sydney, Australia |
| Abstract: | BackgroundThere is conflicting information as to whether antiretroviral drugs with better central nervous system (CNS) penetration (neuroHAART) assist in improving neurocognitive function and suppressing cerebrospinal fluid (CSF) HIV RNA. The current review aims to better synthesise existing literature by using an innovative two-phase review approach (qualitative and quantitative) to overcome methodological differences between studies. |
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