Effect of nitric oxide on expression of apoptotic genes and HSP70 in drosophila |
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Authors: | L B Djansugurova |
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Institution: | 1.Institute of General Genetics and Cytology,Almaty,Kazakhstan |
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Abstract: | Data on involvement of nitric oxide in apoptosis are contradictory. The balance between anti- and proapoptotic activities
of nitric oxide depends on many factors, including its concentration in a tissue and interactions with other regulators of
apoptosis. This paper describes the results of a series of experiments on the effect of nitric oxide donors and inhibitors
as well as dNOS1 and dNOS4 transgenes on the apoptosis on drosophila Lobe
RSV
mutant strain and wild-type strain Oregon R. It has been shown that a high nitric oxide content in cells is able to inhibit antiapoptotic effect of HSP70 and stimulate
apoptosis, possibly, via the grim-mediated apoptotic pathway. Moreover, long-term action of a high nitric oxide concentration during the entire development
more efficiently stimulates the proapoptotic genes as compared with short-term action of this agent. |
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