Enhanced enantioselectivity of lipase from Pseudomonas sp. at high temperatures and fixed water activity in the ionic liquid, 1-butyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]amide |
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Authors: | Marrit Eckstein Peter Wasserscheid Udo Kragl |
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Affiliation: | (1) Fachbereich Chemie, Technische Chemie, Universität Rostock, A.-Einstein-Str. 3a, 18059 Rostock, Germany;(2) Institut für Technische Chemie und Makromolekulare Chemie, RWTH Aachen, Worringerweg 1, 52074 Aachen, Germany |
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Abstract: | The water activity equilibration over saturated salt solutions was monitored in the ionic liquid 1-butyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]amide and in two organic solvents (methyl tert-butylether and n-hexane). Water uptake by the ionic liquid was comparable to that in polar organic solvents. Furthermore, the kinetic resolution of (R,S)-1-phenylethanol catalysed by a lipase from Pseudomonas sp. had a higher selectivity in the ionic liquid at low water activities (aW<0.53) than in methyl tert-butylether. At 60–90 °C E-values of about E150 occured in the ionic liquid, while the enantioselectivity drops to values of 4 in methyl tert-butylether at the same temperatures. |
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Keywords: | ionic liquid kinetic resolution lipase water activity |
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