Salinomycin: a new monovalent cation ionophore. |
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Authors: | M Mitani T Yamanishi Y Miyazaki |
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Institution: | Research Division, Kaken Chemical Company, Limited Honkomagome, Bunkyo-ku, Tokyo, 113 Japan |
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Abstract: | The cation discriminations of salinomycin and its derivatives have been studied by measuring complexability with cations and transport rate of them across organic phase. Salinomycin exhibited a great preference for K+ over other monovalent and divalent cations in migrating cations into organic phase in two phase systems. The antibiotic mediated the transport of Na+ and Rb+ as effectively as that of K+ across CCl4 bulk phase, but not those of Cs+, Mg2+, Ca2+, Sr2+. From the above results, salinomycin is concluded to act as an alkali ion carrier. The OH-acylated salinomycins retained the activity of parent compound, but the COOH-esterified salinomycins lost the activity. |
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