Metabolism of steroid acetates by Streptomyces albus |
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| Authors: | A Mukherjee S B Mahato |
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| Affiliation: | 1. Département de Biochimie, de Microbiologie et de Bio-informatique, IBIS and PROTEO, Université Laval, Québec G1V 0A6, Canada;2. Department of Biomedical and Molecular Sciences, Queen''s University, Kingston, Ontario K7L 3N6, Canada;3. CNRS, Unité de Recherche Mixte CNRS/Aix-Marseille Université (UMR 7281), Laboratoire de Bioénergétique et Ingénierie des Protéines, 13009 Marseille, France;1. Department of Pharmacognosy, School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, PR China;2. Key Laboratory of Plant Resources and Chemistry in Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China |
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| Abstract: | Fermentation of 16-dehydropregnenolone acetate (1a) with Streptomyces albus yielded 16-dehydropregnenolone (1b) and 16-dehydroprogesterone (IIa). Similar incubation of pregnenolone acetate (Ic) with the strain afforded pregnenolone (Id), progesterone (IIb) and 20 alpha-hydroxy progesterone (IIc) while dehydroepiandrosterone acetate (IIIa) under the conditions was converted to dehydroepiandrosterone (IIIb), androstenedione (IVa) and testosterone (IVc). The strain was also capable of converting testosterone acetate (IVb) having the 17-acetoxy function in the 5-membered D-ring to testosterone (IVc) and androstenedione (IVa). All the products were identified by the application of various chemical and spectrometric techniques. |
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