海马CA1区锥体细胞树突分级峰电位的模型分析

脑神经元复杂的树突树结构和电压激活离子通道赋予其复杂的信息整合功能。通过神经元形态的分枝结构模型和电压激活离子通道动力学模型 ,包括远端树突高密度A型K 通道 ,对海马CA1区锥体细胞树突的信息整合特性进行了仿真研究。结果表明 ,远端树突峰电位在很大范围内具有分级放大作用 ,在一定的刺激条件下峰电位的发起部位可在树突轴上移动 ,并且轴突反传动作电位幅度在远端树突会发生突然减小。

MODEL ANALYSIS OF GRADED DENDRITIC SPIKESIN HIPPOCAMPAL CA1 PYRAMIDAL CELLS

Neurons in the brain are endowed with complex information processing functions by their complex dendritic tree structures and voltage-gated ion channels. The neuronal information integration properties were investigated by means of branch morphological model and voltage-gated ion channel kinetic models, including the transient K channel. The results show that the voltage level of distal dendritic spikes is graded in a large range of input intensity, the initiation site of action potential can shift along the apical dendrite, and the amplitude of the back-propagating spike can decrease abruptly when it reaches the distal dendrite.