Effect of polynucleotides on the dimerization of glycine |
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| Authors: | Hiroshi Mizutani Cyril Ponnamperuma |
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| Affiliation: | (1) Laboratory of Chemical Evolution, Department of Chemistry, University of Maryland, 20742 College Park, MD, USA;(2) Present address: Laboratory of Biogeochemistry and Sociogeochemistry, Mitsibishi-Kasei Institute of Life Sciences, 11 Minamiooya, 194 Machida, Tokyo, Japan |
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| Abstract: | Polynucleotides were found to suppress the dimerization reaction of aqueous glycine with trimetaphosphate as the condensing agent. Small anions (chloride, acetate, and phosphate) did not show this effect. The reaction was studied at a pH of about 11.5 and at 70°C and room temperature with a 13 mM concentration of glycine and trimetaphosphate. Under these conditions, the effect of the polynucleotides was in the following order: polyguanylic acid < polycytidylic acid < polyadenylic acid < polyuridylic acid. The result may have a significant implication for the understanding of processes of chemical evolution. |
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