Facile synthesis of (Z)-tetracos-5-enoic acid and racemic cis-4-(2-octadecylcyclopropane-1-yl)-butanoic acid |
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Authors: | Coxon Geoffrey D Douglas James D Minnikin David E |
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Affiliation: | Department of Chemistry, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK. |
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Abstract: | (Z)-tetracos-5-enoic acid and racemic cis-4-(2-octadecylcyclopropane-1-yl)-butanoic acid have been prepared from 1-eicosene by a new facile route. Periodic acid cleavage of the epoxide of 1-eicosene gave nonadecanal which was condensed with 4-carboxybutyltriphenylphosphonium bromide to give predominately (Z)-tetracos-5-enoic acid. Simmons-Smith type cyclopropanation of (Z)-tetracos-5-enoic acid gave a minor proportion of racemic cis-4-(2-octadecylcyclopropane-1-yl)-butanoic acid accompanied by major amounts of its methyl ester. |
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Keywords: | Fatty acids Mycolic acids Cyclopropane rings Wittig reaction Alkene stereochemistry |
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