Kainic acid lesion-induced spatial memory deficits of rats |
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| Authors: | Lucian Hritcu Toshitaka Nabeshima |
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| Institution: | (1) Department of Biology, “Alexandru Ioan Cuza” University, 700506 Iasi, Romania;(2) Department of Chemical Pharmacology, Meijo University, Graduate School of Pharmaceutical Sciences, 468-8503 Nagoya, Japan |
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| Abstract: | The effects of lesioning the ventral tegmental area (VTA) or substantia nigra (SN) neurons by means of bilateral stereotaxic
microinjections of kainic acid (KA) (0.4 mM) were investigated to clarify the role of the VTA and the SN neurons in learning
and memory processes. The present study demonstrates that KA in the SN and the VTA lesioned rats significantly decreased spontaneous
alternation in Y-maze task, working memory and reference memory in radial 8 arm-maze task, suggesting effects on spatial memory
performance. Our findings provide further support for the role of the VTA and the SN neurons in processing and storage of
information. |
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| Keywords: | Kainic acid Working memory Reference memory Substantia nigra Ventral tegmental area |
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