Effects of nutritional stress on brain tyramine concentration and dopamine turnover |
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| Authors: | S. V. Bhave S. D. Telang D. A. Durden A. V. Juorio |
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| Affiliation: | (1) Neuropsychiatric Research Unit, University of Saskatchewan, CMR Building, S7N OWO Saskatoon, Saskatchewan, Canada;(2) Present address: Department of Biochemistry, Faculty of Science, M.S. University of Baroda, 390 002 Baroda, India |
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| Abstract: | This is an investigation of the effect of nutritional stress at various ages on the levels of thep- andm-isomers of tyramine in the caudate nucleus of the rat. For comparison, the effects of nutritional stress on the concentration and turnover of dopamine were also studied. Nutritional stress induced in pre-weaning (3 weeks of age) or post-weaning (up to 9 weeks of age) rats resulted in a decrease in the concentration ofp-tyramine and an increase in the concentration ofm-tyramine in the caudate nucleus. Dopamine concentration or turnover in the caudate nucleus was not affected by pre-weaning undernutrition; in the olfactory tubercles, however, a significant decrease was observed in dopamine turnover, calculated from the decrease in homovanillic acid levels after monoamine oxidase inhibition. The results suggest the changes observed are dependent on the availability of the amino acid precursorsp- andm-tyrosine and their competition towards aromatic-l-amino acid decarboxylase. |
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| Keywords: | p-Tyramine m-tyramine dopamine concentration dopamine turnover nutritional stress |
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