miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary |
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| Authors: | Lin Fei Li Ran Pan Zeng Xiang Zhou Bo Yu De Bing Wang Xu Guang Ma Xue Shan Han Jing Shen Ming Liu Hong Lin |
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| Institution: | Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China. |
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| Abstract: | More than 99% of ovarian follicles undergo atresia in mammals, but the mechanism of follicular atresia remains to be elucidated. In this study, we explored microRNA (miRNA) regulation of follicular atresia in porcine ovary. A miRNA expression profile was constructed for healthy, early atretic, and progressively atretic follicles, and the differentially expressed miRNAs were selected and analyzed. We found that miR-26b, which was upregulated during follicular atresia, increased the number of DNA breaks and promoted granulosa cell apoptosis by targeting the ataxia telangiectasia mutated gene directly in vitro. |
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