Genetic instability in Drosophila melanogaster. Evidence for insertion mutations |
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Authors: | B Rasmuson M M Green and Britt-Marie Karlsson |
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Institution: | (1) Department of Genetics, University of Umeå, Sweden;(2) Department of Genetics, University of California, Davis, CA., U.S.A. |
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Abstract: | Summary An X chromosome in Drosophila melanogaster is described which is mutationally unstable. Mutational events were identified through phenotypic changes associated with a tandem duplication of the X chromosome in which the white locus is present in duplicate. The left segment of the tandem duplication was marked with the mutant w
sp, the right segment with mutant w
17G. Some of the phenotypic changes were identified as deletions involving the w
17G marked segment of the duplication. Other phenotypic changes involved the left segment in which phenotypically w
sp mutated to w. Experimental evidence is presented which attributes these latter mutations to insertions of foreign DNA into the w locus equivalent to the insertion mutations of E. coli. |
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