Protein kinase and cyclic AMP levels in differentiating myoblasts are altered by extracellular calcium |
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Authors: | GE Morris |
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Institution: | School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, U.K. |
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Abstract: | Protein kinase specific activities and cyclic AMP levels show a similar pattern of response, when the Ca2+ concentration is altered in the culture medium of differentiating chick skeletal muscle cells; an increase at intermediate Ca2+ concentrations (0.05–0.2mM), followed by a decrease at higher concentrations (2mM). Effects of Ca2+ on protein kinase appear to be on cyclic AMP-independent enzymes in both nucleus and cytoplasm, and are quite the reverse of Ca2+ effects on the muscle-specific enzyme, creatine kinase. |
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