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Inhibition of myoblast fusion by tunicamycin and pantomycin |
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| Authors: | Brian M. Gilfix Bishnu D. Sanwal |
| Affiliation: | Department of Biochemistry Medical Science Building University of Western Ontario London, Ontario, N6A 5C1 Canada |
| Abstract: | The formation of myotubes by a continuous rat myoblast line, L6, can be inhibited by non-toxic concentrations of tunicamycin and pantomycin. The effect of tunicamycin, an inhibitor of UDP-N-acetyl-glucosamine: dolichol phosphate N-acetylglucosaminyltransferase, could be reversed by N-acetylglucosamine but not by mannose, glucose or UDP-N-acetylglucosamine. |
| Keywords: | TMN tunicamycin PTN pantomycin Hepes 4-(2-hydroxy-ethyl)-1-piperazineethanesulfonic acid Man D-mannose GlcN D-glucosamine GlcNAc N-acetyl-D-glucosamine |
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