Trypsin-induced masking of tetrodotoxin receptor of the sodium channels in mollusc neurones |
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| Authors: | Nicholas K Chemeris Larisa S Bocharova Vitaliy I Geletyuk |
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| Institution: | Laboratory of Nerve Cell Biophysics, Institute of Biological Physics, U.S.S.R. Academy of Sciences, Pushchino, Moscow Region 142292 U.S.S.R. |
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| Abstract: | At the early stage of trypsin treatment of mollusc neurones tetrodotoxin cannot block the Na+ current. In the course of further exposure of neurones to trypsin, tetrodotoxin-sensitivity is restored completely, so its temporal loss results from shielding rather than destruction of the tetrodotoxin-binding site. Pronase and papain do not affect the tetrodotoxin action on the Na+ current. |
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| Keywords: | Action potential Tetrodotoxin sensitivity Trypsin treatment (Mollusc neurone) |
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