Hepatic cytochrome P-450 in chronically hypoxemic rats |
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| Authors: | L.C. Ou J. Healey H.L. Bonkowsky P. Sinclair |
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| Affiliation: | 1. Department of Physiology Dartmouth - Hitchcock Medical Center Hanover, New Hampshire 03755 USA;2. Department of Medicine Dartmouth - Hitchcock Medical Center Hanover, New Hampshire 03755 USA;3. Department of Biochemistry Dartmouth - Hitchcock Medical Center Hanover, New Hampshire 03755 USA;4. Hepatology/Metabolism Research Laboratory VA Medical Center White River Jct., Vermont 05001 USA |
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| Abstract: | The basal level of hepatic cytochrome P-450 and its inducibility by phenobarbital pretreatment have been found to be enhanced by chronic hypoxemia. Pentobarbital sleeping times were decreased in parallel to changes in levels of cytochrome P-450. The increase in level of hepatic cytochrome P-450 in chronically hypoxemic rats occurred despite the increased levels of hepatic heme oxygenase which previously were associated with the chronic hemoglobinemia of the hypoxemic state. Chronically hypoxemic rats may provide a useful model for study of control of hepatic heme and hemoprotein metabolism. |
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