Effects of asbestos on membrane transport and metabolism of benzo(a)pyrene |
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| Authors: | C. Kandaswami,P.J. O&#x Brien |
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| Affiliation: | Department of Biochemistry Memorial University of Newfoundland St. John''s, Newfoundland A1B 3X9, Canada |
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| Abstract: | The effect of asbestos on benzo(a)pyrene uptake by microsomal membranes and lipid micelles has been investigated. Asbestos mediates a rapid transport of the carcinogen into the membrane and also impairs benzo(a)pyrene metabolism in rabbit and rat liver microsomes by markedly inhibiting aryl hydrocarbon hydroxylase. |
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