Identification of tertiary aminomethylenedioxy-propiophenones as urinary metabolites of safrole in the rat and guinea pig |
| |
Authors: | E.O. OswaldL. Fishbein B.J. CorbettM.P. Walker |
| |
Affiliation: | National Institute of Environmental Health Sciences, National Istitutes of Health, Public Health Service and Department of Health, Education and Welfare, P.O. Box 12233, Research Triangle Park, N.C. 27709 U.S.A. |
| |
Abstract: | Three nitrogen-containing metabolites of safrole (1-allyl-3,4-methylenedioxy-benzene) are excreted in the urine of rats and/or guinea pigs following oral or intraperitoneal administration. The major safrole basic ninhydrin-positive metabolites of the guinea pig and rat are 3-N-N-dimethylamino-1-(3′,4′-methylenedioxyphenyl)-1-propanone and 3-piperidyl-1-(3′,4′-methylenedioxyphenyl)-1-propanone, respectively. In addition, the rat also excretes the above N,N-dimethylaminoketone and trace amounts of 3-pyrrolidinyl-1-(3′,4′-methylenedioxyphenyl)-1-propanone. All three of these aminoketones decompose to form 1-(3′,4−methylenedioxyphenyl)-3-propen-1-one. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|