| 甲醛炎性痛及痛过敏诱导大鼠脊髓后角环氧化酶-2表达的变化 |
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| 作者姓名： | Li SQ Li WB Sun XC Li QJ Chen XL Ai J |
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| 作者单位： | 河北医科大学基础所病理生理学研究室,河北,石家庄,050017 |
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| 摘 要： | 目的:观察甲醛炎性痛及痛过敏过程中脊髓后角环氧化酶-2 (COX-2)表达的变化及其时间特征.方法:采用大鼠甲醛疼痛模型,用免疫组化法观察脊髓COX-2表达的变化.结果:与对照组相比,注射甲醛后4 h,1 d及3 d组脊髓后角Ⅰ-Ⅵ板层COX-2免疫反应阳性细胞的数目及染色深度均显著增加,以1 d组增加最为明显.结论:脊髓后角COX-2参与甲醛炎性痛及痛过敏.
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| 关 键 词： | 炎性痛及痛过敏 环氧化酶-2(COX-2) 脊髓 免疫组织化学方法 |
| 文章编号： | 1000-6834(2004)03-0296-04 |
Changes of COX-2 expression in the dorsal horn of the spinal cord during formalin-induced inflammatory pain and hyperalgesia in rats |
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| Li SQ,Li WB,Sun XC,Li QJ,Chen XL,Ai J.Changes of COX-2 expression in the dorsal horn of the spinal cord during formalin-induced inflammatory pain and hyperalgesia in rats[J].Chinese Journal of Applied Physiology,2004,20(3):296-299,F009. |
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| Authors: | Li Shu-qin Li Wen-bin Sun Xiao-cai Li Qing-jun Chen Xiao-ling Ai Jie |
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| Institution: | Department of Pathophysiology, Institute of Basic Medicine, Hebei Medical University, Hebei Shijiazhuang 050017, China. |
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| Abstract: | |
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| Keywords: | inflammatory pain and hyperalgesia cyclooxygenase-2 spinal cord immunohistochemistry |
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