微小RNA-129在肿瘤发生中的作用机制

微小RNA-129（microRNA-129, miR-129）是一种能产生miR-129-5p、miR-129-1-3p和miR-129-2-3p等3种成熟产物的miRNA，它们在细胞生长、发育、癌变等生命过程中有重要作用. miR-129在多种常见肿瘤中呈现高表达（如：胃癌和肺癌）或低表达（如：乳腺癌和食管鳞状细胞癌）的多样现象，而且这种异常表达与肿瘤的发生发展有密切联系. miR-129通过作用于性别决定区Y框蛋白4（sex-determining-region Y-box 4, SOX4）、细胞周期蛋白依赖激酶6（cyclin-dependent kinase 6, Cdk6）、含缬酪肽蛋白（valosin containing protein, VCP）和磷脂酰肌醇蛋白聚糖-3（glypican-3, GP3）等多种靶基因而在肿瘤发生、发展过程中起着重要作用.

Working Mechanisms of MicroRNA-129 in Tumorigenesis

MicroRNA-129 (miR-129) is a gene family, which consists of miR-129-5p, miR-129-1-3p and miR-129-2-3p. They played an important role in many life activities, such as cell growth, development and carcinogenesis. miR 129 often abnormally expressed in a variety of common tumors, and the abnormal expression was closely associated with tumorigenesis. For example, they were up-regulated in gastric cancer and lung cancer or down regulated in breast cancer and esophageal squamous cell carcinoma. miR-129 plays key roles in tumorigenesis by regulating the expression of its targets such as sex-determining region Y-box 4 (SOX4), cyclin-dependent kinase 6 (Cdk6), valosin containing protein (VCP) and glypican-3 (GP3).