Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of Allium cepa root tips |
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Authors: | Unal Meral Palavan-Unsal Narcin Tufekci M A |
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Institution: | Department of Biology, Arts and Sciences Faculty, Marmara University, Goztepe 81040, Istanbul, Turkey. |
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Abstract: | The genotoxic and cytotoxic effects of exogenous polyamines (PAs), putrescine (Put), spermidine (Spd), spermine (Spm) and PA biosynthetic inhibitors, alpha-difluoromethylornithine (DFMO), cyclohexilamine (CHA), methylglioxal bis-(guanylhydrazone) (MGBG) were investigated in the root meristems of Allium cepa L. The reduction of mitotic index and the induction of chromosomal aberrations such as bridges, stickiness, c-mitotic anaphases, micronuclei, endoredupliction by PAs and PA biosynthetic inhibitors were observed and these were used as evidence of genotoxicity and cytotoxicity. |
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