Murine peripherin gene sequences direct Cre recombinase expression to peripheral neurons in transgenic mice |
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Authors: | Zhou Li Népote Virginie Rowley Daniel L Levacher Béatrice Zvara Agnes Santha Miklos Mi Qing Sheng Simonneau Michel Donovan David M |
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Affiliation: | Department of Internal Medicine, Biochemistry Section, University of Perugia, 06122 Perugia, Italy. |
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Abstract: | Group B streptococcus (GBS) induced macrophage apoptosis by which it could avoid host defence mechanisms. Macrophages, which constitutively express phosphatidylserine (PtdSer) on the outer leaflet of plasma membrane, increased PtdSer exposure during GBS-induced apoptosis. Induction of apoptosis decreased PtdSer radioactivity of macrophages incubated with [3H]serine. The effect appeared not due to increasing conversion of PtdSer to phosphatidylethanolamine or phosphatidylcholine nor to the release of radioactive membrane vesicles. The radioactivity in lysoPtdSer was also reduced. These results confirm that induction of apoptosis involves a modification of PtdSer metabolism and point out the typical features of the GBS-induced apoptosis with respect to other models of apoptosis. |
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Keywords: | Phosphatidylserine Apoptosis Macrophage Group B streptococcus |
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