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Design,synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2 |
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| Authors: | Anatolii R Syniugin Olga V Ostrynska Maksym O Chekanov Galyna P Volynets Sergiy A Starosyla Volodymyr G Bdzhola |
| Institution: | 1. Department of Medicinal Chemistry, Institute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraineasinugin@gmail.com;3. Department of Medicinal Chemistry, Institute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine |
| Abstract: | AbstractIn this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 compounds inhibiting CK2 with IC50 in the range from 0.65 to 18.2?μM were identified. The most active inhibitors were found among tetrazolo-quinoline-4-carboxylic acid and 2-aminoquinoline-3-carboxylic acid derivatives. |
| Keywords: | Inhibitor protein kinase CK2 tetrazolo[1 5-a]quinoline-4-carboxylic acid 2-aminoquinoline-3-carboxylic acid 2-chloroquinoline-3-carboxylic acid 2-oxo-1 2-dihydroquinoline-3-carboxylic acid 5-oxo-2 3-dihydro-1H 5H-pyrido[3 2 1-ij]quinoline-6-carboxylic acid |