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Effects of prenatal diclofenac sodium exposure on newborn testis: a histomorphometric study
Authors:H Arslan  A Aktaş  E Elibol  OBB Esener  AP Türkmen  KK Yurt
Institution:1. Department of Molecular and Technical Medicine, Faculty of Medical Life Sciences, Hochschule Furtwangen University, Villingen-Schwenningen, Germany;2. Department of Histology and Embryology, School of Veterinary Medicine, ?stanbul University Istanbul, Turkey;3. Department of Histology and Embryology, Medical School, Ad?yaman University, Ad?yaman, Turkey;4. Department of Histology and Embryology, Medical School, Ondokuz May?s University, Samsun, Turkey
Abstract:Diclofenac sodium (DS) is used primarily to treat fever and to alleviate pain and inflammation. We investigated the effects of DS exposure during gestation on the testes of rat pups to investigate the safety of its use during the prenatal period. Pregnant rats were separated into control, saline, low dose, medium dose and high dose groups. DS was given between weeks 15 and 21 of gestation. Total numbers of spermatogonia and Sertoli cells were counted in the testes of 7-day-old male rats using the physical disector method. By the end of the study, the total number of Sertoli cells was decreased significantly in a dose dependent manner in the medium and high dose groups compared to controls. No significant differences were found in the total number of spermatogonia in the control, saline and low dose DS groups. Medium and high dose DS administration reduced the total number of spermatogonia compared to other groups. We suggest that prenatal administration of DS can cause deleterious effects on the testis development, especially in high doses.
Keywords:diclofenac sodium  physical disector  rat  Sertoli cells  spermatogonia  stereology  testis
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