Intracellular Assembly and Trafficking of MHC Class I Molecules |
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Authors: | Julie G Donaldson David B Williams |
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Institution: | Laboratory of Cell Biology, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA; Departments of Biochemistry and Immunology, Medical Sciences Building, University of Toronto, Toronto, Canada M5S 1A8 |
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Abstract: | The presentation of antigenic peptides by class I molecules of the major histocompatibility complex begins in the endoplasmic reticulum (ER) where the co-ordinated action of molecular chaperones, folding enzymes and class I-specific factors ensures that class I molecules are loaded with high-affinity peptide ligands that will survive prolonged display at the cell surface. Once assembled, class I molecules are released from the quality-control machinery of the ER for export to the plasma membrane where they undergo dynamic endocytic cycling and turnover. We review recent progress in our understanding of class I assembly, anterograde transport and endocytosis and highlight some of the events targeted by viruses as a means to evade detection by cytotoxic T cells and natural killer cells. |
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Keywords: | antigen presentation endocytosis endoplasmic reticulum membrane traffic molecular chaperones peptide loading complex ubiquitylation |
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