Chemical constituents from the stems of Tripterygium regelii |
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| Institution: | 1. Key Lab for New Drug Research of TCM and Shenzhen Branch, State R&D Centre for Viro-Biotech, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, Guangdong, People''s Republic of China;2. Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, Zhanjiang 524023, Guangdong, People''s Republic of China;3. School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China;1. School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Jinghai District, Tianjin 301617, PR China;2. Second Affiliated Hospital of Tianjin University of TCM, Hebei District, Tianjin 300250, PR China;3. Guangdong Pharmaceutical University, Panyu District, Guangzhou 510006, PR China |
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| Abstract: | Phytochemical investigation on the stems of Tripterygium regelii resulted in the isolation of fourteen compounds, including six flavonoids (1–6), seven lignans (7–13), and one cyanogenic glycoside (14). This is the first report of the four dimeric flavonoids bis-8, 8′-catechinylmethane (2), bis (8-epicatechinyl) methane (3), bis-6, 8′-catechinylmethane (4) and montahomobisflavan B (5) from a species of Tripterygium. Previously, these dimeric flavonoids have been mainly identified from species of gymnosperms. This research has shown that the main secondary metabolisms identified in T. regelii were flavonoids and lignans. These data enable this species to be differentiated from T. wilfordii and T. hypoglaucum that contain the triptolide-resembling diterpenoids. |
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| Keywords: | Celastraceae Dimeric flavonoids Chemotaxonomic significance |
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