Cooperative Use of VCD and XRD for the Determination of Tetrahydrobenzoisoquinolines Absolute Configuration: A Reliable Proof of Memory of Chirality and Retention of Configuration in Enediyne Rearrangements |
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| Authors: | Shovan Mondal Jean‐Valère Naubron Damien Campolo Michel Giorgi Michéle P Bertrand Malek Nechab |
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| Institution: | 1. Aix‐Marseille Université, CNRS ICR UMR7273, , Marseille, France;2. Aix‐Marseille Université, Spectropole, Fédération de Chimie, , Marseille, France |
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| Abstract: | The absolute configurations (AC) of azaheterocylic compounds resulting from the cascade rearrangement of enediynes involving only light atoms were unambiguously assigned by the joint use of vibrational circular dichroism (VCD) and copper radiation single crystal X‐ray diffraction (XRD). These AC determinations proved that the rearrangements of enediynes proceeded with memory of chirality and retention of configuration. Chirality 25:832–839, 2013. © 2013 Wiley Periodicals, Inc. |
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| Keywords: | VCD X‐ray diffraction enediynes memory of chirality absolute configurations heterocycles |
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