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Incorporation of mannose and glucose into prenylphosphate sugars in isolated human platelet membranes |
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| Authors: | S De Luca |
| Institution: | American National Red Cross, Blood Research Laboratory, 9312 Old Georgetown Road, Bethesda, Md. 20014 U.S.A. |
| Abstract: | Isolated platelet membranes synthesize mannosylretinyl phosphate and dolichylmannosyl phosphate from GDP-14C]mannose, but only dolichylglucosyl-phosphate is synthesized from UDP-14C]glucose.Addition of exogenous retinylphosphate specifically stimulates the biosynthesis of mannosylretinylphosphate. |
| Keywords: | GDPMan guanosine diphosphate-mannose UDPG uridine diphosphate-glucose UDPGal uridine diphosphate-galactose DMSO dimetylsulfoxide DMP dolichylmannosylphosphate MRP mannosylretinylphosphate RP retinylphosphate |
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