Cytotoxic ent‐Kaurane Diterpenoids from Isodon nervosus |
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| Authors: | You‐Heng Gao Zhi‐Xiong Wei Yi Cheng Teng‐Hua Wang Lin Ni Xiao‐Hong Zhou Li‐Yuan Zhang |
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| Affiliation: | 1. Department of Phytochemistry, School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, P.?R. China;2. DongGuan Institute for Food and Drug Control, Dongguan 523106, P.?R. China, (phone: +86‐20‐39358083) |
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| Abstract: | Four new ent‐kaurane diterpenoids, rabdonervosins G–J ( 1 – 4 , resp.), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated by extensive spectroscopic analyses, including 1D‐, 2D‐NMR and HR mass spectra. Compound 2 showed potent cytotoxicity against the HepG2 and PC‐9/ZD cell lines with IC50 values of 2.36 and 6.07 μM , respectively, and compound 3 exhibited cytotoxicity against the HepG2 and CNE2 cell lines with IC50 values of 8.64 and 9.77 μM , respectively. |
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| Keywords: | Isodon nervosus ent‐Kaurane diterpenoids Terpenoids Rabdonervosins G – J Cytotoxic activity |
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