Enantiomeric Separation of 13 New Amphetamine‐Like Designer Drugs by Capillary Electrophoresis,Using Modified‐‐Cyclodextrins |
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Authors: | Lucia Burrai Maria Nieddu Maria Antonietta Pirisi Antonio Carta Irene Briguglio Gianpiero Boatto |
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Affiliation: | Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, , Sassari, Italy |
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Abstract: | An easy‐to‐prepare chiral CE method for the enantiomeric separation of 13 new amphetamine‐like designer drugs, using CDs as chiral selectors, was developed. Sulfated‐β‐CD was found to be the best chiral selector among the three used (sulfated‐β‐CD, caroboxymethyl‐β‐CD, dimethyl‐β‐CD). The separation of the analytes was achieved in a fused‐silica gel capillary at 20 °C using an applied voltage of +25 kV. The optimized background electrolyte consisted of 63.5 mM H3PO4 and 46.9 mM NaOH in water. Several electrophoretic parameters such as CD type, CD concentration (1 ? 40 mg/mL), buffer pH (2.6, 3.6, 5.0, 6.0), length of the capillary (70 ? 40 cm total length), amount of the organic solvent (methanol and acetonitrile) were investigated and optimized. Chirality 25:617–621, 2013. © 2013 Wiley Periodicals, Inc. |
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Keywords: | trimethoxy‐amphetamines dimethoxy‐amphetamines paramethoxy‐amphetamines S‐β ‐cyclodextrin CM‐β ‐cyclodextrin DM‐β ‐cyclodextrin chiral separation |
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