Two Novel Potent α‐Amylase Inhibitors from the Family of Acarviostatins Isolated from the Culture of Streptomyces coelicoflavus ZG0656 |
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| Authors: | Peng Geng Ting Sun Qiping Zhong Xiaoxia Li Liying Shi Fang Bai Gang Bai |
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| Institution: | 1. Tianjin State Laboratory of Cellular and Molecular Immunology, Department of Microbiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, P.?R. China, (phone: +86‐22‐83336816);2. Basic Medical Research Center, Tianjin Medical University, Tianjin 300070, P.?R. China;3. College of Pharmaceutical Sciences, Nankai University, Tianjin 300071, P.?R. China |
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| Abstract: | Two novel aminooligosaccharides were separated from the culture filtrate of Streptomyces coelicoflavus ZG0656. Their chemical structures were determined by acidic hydrolysis, electrospray‐ionization tandem mass spectrometry (ESI‐MS/MS), and NMR spectroscopy. The compounds were named acarviostatins III0(?1) and III23 according to the nomenclature of this group of metabolites. The two novel acarviostatins were both mixed noncompetitive inhibitors of porcine pancreatic α‐amylase (PPA). The inhibition constants (Ki) for acarviostatins III0(?1) and III23 were 0.009 and 0.026 μM , respectively, 151 and 52 times more potent than acarbose. |
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| Keywords: | Streptomyces coelicoflavus Acarviostatins III0(− 1) and III23 α ‐Amylase Inhibitiors Saccharide hydrolase |
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