Enantioselective Liquid–Liquid Extraction of Zopiclone With Mandelic Acid Ester Derivatives |
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| Authors: | Yangfeng Peng Quan He Bin Zuo Haibo Niu Tianzhong Tong Hongliang Zhao |
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| Institution: | 1. Department of Chemical Engineering, East China University of Science and Technology, , Shanghai, China;2. Department of Engineering, Faculty of Agriculture, Dalhousie University, , Truro, Nova Scotia, Canada |
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| Abstract: | Enantioselective liquid–liquid extraction of zopiclone was conducted by employing a series of (R)‐mandelic acid esters as chiral extractants. The effects of concentration of extractant, concentration of zopiclone, type of organic solvent, pH value, and temperature on the extraction efficiency were investigated. (R)‐o‐chloromandelic acid propyl ester was demonstrated to be an efficient chiral extractant for zopiclone resolution with a maximum enantioselectivity of 1.6. Chirality 25:952–956, 2013. © 2013 Wiley Periodicals, Inc. |
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| Keywords: | enantioselective extraction enantiomer zopiclone mandelic acid ester chiral recognition |
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