Use of Sulfated Cyclofructan 6 and Sulfated Cyclodextrins for the Chiral Separation of Four Basic Pharmaceuticals by Capillary Electrophoresis |
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| Authors: | Yi Jun Zhang Ming Xian Huang Yu Ping Zhang Daniel Wayne Armstrong Zachary S. Breitbach Jae Jeong Ryoo |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, , Xinxiang, P. R. China;2. Department of Chemistry, Graduate School, Kyungpook National University, , Daegu, Korea;3. Department of Chemistry, University of Texas at Arlington, , Arlington, Texas, USA;4. Department of Chemistry Education and Green‐Nano Materials Research Center, Kyungpook National University, , Daegu, Korea |
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| Abstract: | Sulfated cyclofructan 6 (S‐CF6) and sulfated cyclodextrins (S‐α‐, β‐, γ‐CDs) are highly selective chiral selectors for the enantioseparation of basic solutes. In this study, S‐CF6 was introduced for the enantiomeric separation of four basic pharmaceuticals (including tamsulosin, tiropramide, bupivacaine, and norephedrine) by capillary electrophoresis (CE), and the enantiomeric separation performance was compared with S‐α‐, β‐, γ‐CDs. The effects of the chiral selector type, chiral selector concentration, operating voltage, and column temperature were examined and optimized. Excellent resolutions were obtained for all solutes on these chiral selectors. Chirality 25:735–742, 2013. © 2013 Wiley Periodicals, Inc. |
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| Keywords: | capillary electrophoresis chiral separations sulfated cyclofructan 6 sulfated cyclodextrins basic pharmaceuticals |
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