Cancer Chemopreventive Effect of Bergenin from Peltophorum pterocarpum Wood |
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| Authors: | Jie Zhang Yuki Nishimoto Harukuni Tokuda Nobutaka Suzuki Ken Yasukawa Worapong Kitdamrongtham Hiroyuki Akazawa Aranya Manosroi Jiradej Manosroi Toshihiro Akihisa |
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| Affiliation: | 1. College of Science and Technology, Nihon University, 1‐8‐14 Kanda Surugadai, Chiyoda‐ku, Tokyo 101‐8308, Japan;2. Graduate School of Medical Science, Kanazawa University, 13‐1 Takara‐machi, Kanazawa 920‐8640, Japan;3. School of Pharmacy, Nihon University, 7‐7‐1 Narashinodai, Funabashi‐shi, Chiba 274‐8555, Japan;4. Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand, (phone: +66‐53‐944338;5. fax: +66‐53‐894169) |
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| Abstract: | The aqueous extract of Peltophorum pterocarpum (Fabaceae) wood exhibited potent inhibitory effects against Epstein? Barr virus early antigen (EBV‐EA) activation induced with 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) in Raji cells and against melanogenesis in α‐melanocyte‐stimulating hormone (α‐MSH)‐stimulated B16 melanoma cells, as well as potent 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) free radical‐scavenging activity. Two phenolic acid derivatives, bergenin ( 1 ) and gallic acid ( 2 ), were isolated from the ethyl acetate (AcOEt)‐soluble fraction obtained from the extract. Compound 1 exhibited potent inhibitory effect against EBV‐EA activation and against skin tumor promotion in an in vivo two‐stage mouse skin carcinogenesis test based on 7,12‐dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as promoter. Both compounds 1 and 2 exhibited melanogenesis‐inhibitory activities in α‐MSH‐stimulated B16 melanoma cells, and, in addition, compound 2 showed strong DPPH radical‐scavenging activity. |
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| Keywords: | Peltophorum pterocarpum Bergenin Anti‐tumor‐promoting activity Melanogenesis inhibition Antioxidant activity Radical‐scavenging activity |
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