Stereoselective Synthesis of (3R)‐3‐Alkyl‐4,1‐Benzoxazepine‐2,5‐Diones |
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| Authors: | Bushra Nisar Abdul Rauf Raza David Stc Black Naresh Kumar Muhammad Nawaz Tahir |
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| Institution: | 1. Ibn e Sina Block, Department of Chemistry, University of Sargodha, , Sargodha, Pakistan;2. School of Chemistry, University of New South Wales, , Sydney, Australia;3. Ibn ul Hathum Block, Department of Physics, University of Sargodha, , Sargodha, Pakistan |
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| Abstract: | Novel 3‐alkyl‐4,1‐benzoxazepine‐2,5‐diones were synthesized in good ee exploiting the chiral pool methodology, an economical way of asymmetric synthesis. Various anthranilic acids are coupled with different α‐haloacids to afford N‐acylated anthranilic acid intermediates which undergo cyclization to (3R)‐3‐alkyl‐4,1‐benzoxazepines‐2,5‐diones. Chirality 25:865–870, 2013. © 2013 Wiley Periodicals, Inc. |
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| Keywords: | anthranilic acid N‐acylation α ‐halo acids coupling reaction 4 1‐benzoxazepine‐2 5‐diones |
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