Action de la flore microbienne du tractus digestif sur la biosynthese de l'acide cholique chez le rat

Axenic and holoxenic (conventional) rats were fed a diet containing trace amounts of 2,4-³H]cholic and 24-¹⁴C]chenodeoxycholic acids. In the feces of both groups of rats, the percentage of labelled bile acids which were ³H-labelled was slightly different. In the experimental conditions used, the intestinal microflora only slightly modified the synthesis of 12α-hydroxylated bile acids.