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Novel Indole Alkaloids from Nauclea latifolia and Their Renin‐Inhibitory Activities |
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| Authors: | Anthony A Agomuoh Athar Ata Chibuike C Udenigwe Rotimi E Aluko Iwu Irenus |
| Institution: | 1. Department of Biology, Richardson College for the Environmental and Science Complex, The University of Winnipeg, 599 Portage Ave., Winnipeg, MB, Canada R3B 2G3;2. Department of Chemistry, Richardson College for the Environmental and Science Complex, The University of Winnipeg, 599 Portage Ave., Winnipeg, MB, Canada R3B 2G3, (phone: +1‐2047869389;3. fax: +1‐2047752114);4. Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada R3T 2N2;5. Department of Industrial Chemistry, Federal University of Technology, Owerri, Nigeria |
| Abstract: | Chemical studies on the crude MeOH extract of stems and barks of Nauclea latifolia resulted in the isolation of five new indole alkaloids, latifoliamides A–E ( 1 – 5 , resp.), along with one known alkaloid, angustoline ( 6 ). The structures of these compounds were elucidated by means of extensive NMR spectral studies. Compound 1 has a 20‐ethylidenetetrahydrofuran ring incorporated in its structure and represents the first example of this class of indole alkaloids. All of the isolates exhibited moderate in vitro renin inhibitory activities. |
| Keywords: | Nauclea latifolia Renin‐inhibitory activity Indole alkaloids Alkaloids Latifoliamides A – E Angustoline Inhibitors Antihypertensive activity |